Journal article
Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
KL Tan, KH Ling, CA Hewitt, PS Cheah, K Simpson, L Gordon, MA Pritchard, GK Smyth, T Thomas, HS Scott
Genomics Data | Published : 2014
Abstract
The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learning and memory [2,3]. To understand the global gene expression effect of the partially triplicated MMU16 segment on mouse brain development, we performed the spatiotemporal transcriptome analysis of Ts1Cje and disomic control cerebral cortex, cerebellum and hippocampus harvested at four developmental time-points: postnatal day (P)1, P15, P30 and P84. Here, we provide a detailed description of the e..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council fellowships (461204 and APP1023059 to HSS); National Health and Medical Research Council Grants 219176, 257501, and 215201 (to HSS and GKS); Sciencefund Grant, MOSTI, Malaysia (02-01-04-SF1306) awarded to P-SC; Research University Grant Scheme, Universiti Putra Malaysia (04-02-12-2102RU) awarded to K-HL; and the APEX Foundation for Research into Intellectual Disability Limited to CAH. K-LTwas a recipient of the Malaysian Ministry of Higher Education MyPhD scholarship. The microarrays were performed by the Australian Genome Research Facility, which was established through the Commonwealth-funded Major National Research Facilities programme.